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Urinary frequencyacute urinary retentionoliguria with elevated blood pressureazotemiarenal failureand impotenceAlbuminuriaglycosuriaelevated BUNand microscopic deposits in the urine have also been reportedThere have been rare reports of impaired male fertility and/or abnormal spermatogenesis.

Tegretol has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizuresIt appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiationTegretol greatly reduces or abolishes pain induced by stimulation of the infraorbital nerve in cats and ratsIt depresses thalamic potential and bulbar and polysynaptic reflexesincluding the linguomandibular reflex in catsTegretol is chemically unrelated to other anticonvulsants or other drugs used to control the pain of trigeminal neuralgiaThe mechanism of action remains unknown.

Therapy should be prescribed only after critical benefit-to-risk appraisal in patients with a history of cardiac conduction disturbanceincluding second-and third-degree AV heart blockcardiachepaticor renal damageadverse hematologic or hypersensitivity reaction to other drugsincluding reactions to other anticonvulsantsor interrupted courses of therapy with Tegretol.

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