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Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4 inhibitorsSee DRUG INTERACTIONSCombining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity.

Colchicine belongs to a class of drugs called anti-gout medicationsA class of drugs is a group of medications that work in a similar wayThese drugs are often used to treat similar conditions.

No dedicated pharmacokinetic study using colchicine capsules has been conducted in patients with varying degrees of hepatic impairmentColchicine is known to be metabolized in humans and the presence of severe hepatic impairment has been associated with colchicine toxicityHepatic clearance of colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment.

If your doctor directs you to take colchicine regularlyuse it regularly to get the most benefit from itTo help you remembertake it at the same time(seach day.

Colchicine is also available in capsulesThe capsules are available as the brand-name drug MitigareThe capsules are accutane 40mg. also available as generic drugs.

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