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No studies on the effects on the ability to drive and use machines have been performedHoweverwhen driving vehicles or operating machines it must be borne in mind that dizziness or drowsiness may occasionally occur when taking antihypertensive therapyin particular during initiation of treatment or when the dose is increased.

Exposure to AIIRA therapy during the second and third trimesters is known to induce human fetotoxicitydecreased renal functionoligohydramniosskull ossification retardationand neonatal toxicityrenal failurehypotensionhyperkalaemiasee also section 5.3

Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular regulationFurthermore losartan does not inhibit ACEkininase IIthe enzyme that degrades bradykininConsequentlythere is no potentiation of undesirable bradykinin-mediated effects.

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