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Some products that may interact with selegiline includeantidepressantsincluding bupropionmaprotilinemirtazapineother MAO inhibitorsisocarboxazidlinezolidmethylene bluemoclobemidephenelzineprocarbazinerasagilinesafinamidetranylcypromineappetite suppressantssuch as diethylpropiondrugs for attention deficit disordersuch as atomoxetinemethylphenidateapraclonidinebuspironecarbamazepine/oxcarbazepinecyclobenzaprinedeutetrabenazinecertain herbal productssuch as ephedra/ma huangcold medications/nasal decongestantssuch as phenylephrinephenylpropanolaminepseudoephedrinefentanylstreet drugssuch as LSDmescalinestimulantssuch as amphetaminesephedrinesupplementssuch as tryptophantyraminetetrabenazinecertaintriptansused to treat migraine headachessuch as rizatriptansumatriptanzolmitriptanvalbenazine.

Eldepryl is contra-indicated in patients receiving treatment with serotonin-agonistse.gsumatriptannaratriptanzolmitriptan and rizatriptan

Selegiline should be used only when clearly needed during pregnancyDiscuss the risks and benefits with your doctor.

No pharmacokinetic information is available on selegiline or its metabolites in hepatically impaired subjects.

Severe CNS toxicity associated with hyperpyrexia and death have been reported with the combination of tricyclic antidepressants and non-selective MAOIsNARDILPARNATEA similar reaction has been reported for a patient on amitriptyline and ELDEPRYLAnother patient receiving protriptyline and ELDEPRYL developed tremorsagitationand restlessness followed by unresponsiveness and death two weeks after ELDEPRYL was addedRelated adverse events including hypertensionsyncopeasystolediaphoresisseizureschanges in behavioral and mental statusand muscular rigidity have also been reported in some patients receiving ELDEPRYL and various tricyclic antidepressants.

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