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Before using lamivudine-HBVtell your doctor or pharmacist your medical historyespecially ofHIV infectionkidney diseaseblood disordersliver disease.

You may need to break an Epivir tablet in half when giving this medicine to a child for HIVCall your doctor if the child has any trouble swallowing the tablet.

Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapyincluding lamivudineDuring the initial phase of HIV treatmentpatients whose immune system responds to antiretroviral therapy may develop an inflammatory response to indolent or residual opportunistic infectionssuch as progressive multifocal leukoencephalopathyPMLmycobacterium avium complexMACcytomegalovirusCMVPneumocystis carinii pneumoniaPCPor tuberculosisTBwhich may necessitate further evaluation and treatmentIn additionautoimmune diseaseincluding GravesdiseaseGuillain-Barre syndromeand polymyositismay also develop in the setting of immune reconstitutionthe time to onset is variable and may occur months after treatment initiation.

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