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Isoniazid is a prodrug and must be activated by bacterial catalaseSpecficiallyactivation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complexOnce activatedisoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallAt therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organismsSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.

Treatment of latent TB infection greatly reduces the risk that TB infection will progress to acitve disease.

Before taking isoniazidtell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

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