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Hypomagnesemiasymptomatic and asymptomatichas been reported rarely in patients treated with PPIs for at least three monthsin most cases after a year of therapySerious adverse events include tetanyarrhythmiasand seizuresIn most patientstreatment of hypomagnesemia required magnesium replacement and discontinuation of the PPI.

This medicine can cause diarrheawhich may be a sign of a new infectionIf you have diarrhea that is watery or bloodycall your doctor before using anti-diarrhea medicine.

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The duration of proton pump inhibitor administration should be based on available safety and efficacy data specific to the defined indication and dosing frequencyas described in the prescribing informationand individual patient medical needsProton pump inhibitor treatment should only be initiated and continued if the benefits outweigh the risks of treatment.

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