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In th vnt a snsitization sv local iitation om BACTOBAN ointmnt, usag should b discontinud, and appopiat altnativ thapy th inction institutd.
High-lvl mupiocin sistanc ( ? 512 mcg/mL) may b dtmind using standad disk diusion both micodilution tsts. 1,2 Bcaus th occunc mupiocin sistanc in mthicillin-sistant S. auus (MSA), it is appopiat ttst MSA populations mupiocin suscptibility pitth us mupiocin using a standadizd mthod. 3,4,5.
Whn mupiocin sistanc occus, it sults om th poduction a modiid isolucyl-tNA synthtas, th acquisition o, by gntic tans, a plasmid mdiating a nw isolucyl-tNA synthtas. High-lvl plasmid-mdiatd sistanc (MIC ? 512 mcg/mL) has bn potd in incasing numbs isolats S. auus and with high quncy in coagulas-ngativ staphylococci. Mupiocin sistanc occus with gat quncy in mthicillin-sistant than mthicillin-suscptibl staphylococci.
BACTOBAN ointmnt should not b usd with intavnous cannula at cntal intavnous sits bcaus th potntial tpomot ungal inctions and antimicobial sistanc.
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