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PREGNANCY AND BREASTFEEDING SAFETYSotalol crosses the placenta and is found in amniotic fluidSafe use by pregnant women has not been establishedSotalol is excreted in human milkA decision should be made whether to discontinue nursing or to discontinue the drug due to risk of adverse effects in the infant.

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Sotalol is a beta-adrenergic blocking drug that is used to treat abnormal heart rhythmsSotalol is a first generation beta blocker in a class that includes propranololInderalInnoPrannadololCorgardpenbutolol sulfateLevatoltimololBlocadrenand pindololViskenThese drugs differ from other beta blocking drugs because they are non-selective in naturemeaning that they block both beta-1 and beta-2 receptors on nerves andthereforewill affect not only the heart but also the kidneyslungsgastrointestinal tractliveruterusmuscles surrounding blood vesselsand skeletal muscleNorepinephrine and epinephrineadrenalineare chemicals released within the body that attach to receptors on several types of cellsincluding nerves and some musclesAttachment changes the way the cells functioneither stimulating the cells or suppressing themin part through beta receptorsSotalol prevents norepinephrine and epinephrine from binding to beta receptors on nervesBy blocking the effect of norepinephrine and epinephrinebeta blockers reduce heart ratereduce the force of the heart’s contractionsand reduce blood pressure by relaxing the muscles surrounding the blood vesselsSotalol also directly reduces the rate at which the heart beats by reducing the rapidity of firing of the normal generator of electrical impulses in the heartthe heart’s pacemakerThe FDA approved sotalol in October1992.

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