Taking estrace, or any hormones may increase your risk of blood clots, stroke, or a heart attack, particularly if you have diabetes, high blood pressure, high cholesterol or triglycerides, if you are overweight or if you smoke.

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The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women with daily oral conjugated estrogensCEaloneThe WHI estrogen-plus-progestin substudy reported increased risks of DVTpulmonary embolismstrokeand myocardial infarction in postmenopausal women with daily oral CE combined with medroxyprogesterone acetateMPAIn the absence of comparable datathese risks should be assumed to be similar for other dosage forms of estrogens.

Using estrogens with or without progestins may increase your chances of getting heart attacksstrokesbreast cancerand blood clotsUsing estrogens with progestins may increase your risk of dementiaYou and your healthcare provider should talk regularly about whether you still need treatment with Estrace.

Get emergency help immediately if any of the following symptoms of overdose occur while taking estradiol:

The following additional adverse reactions have been reported with estrogen and/or progestin therapy.

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