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To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis.

After a favorable initial response is notedthe proper maintenance dosage should be determined by decreasing the initial dosage in small decrements at appropriate time intervals until the lowest dosage that maintains an adequate clinical response is reached.

Corticosteroids can produce reversible hypothalamic-pituitary adrenalHPAaxis suppression with potential for glucocorticosteroid insufficiency after withdrawal of treatmentadrenocortical insufficiency may result from too rapid withdrawalmay be minimized by gradual reduction of dosagerelative insufficiency may persist for months after discontinuation of therapythereforein any situation of stress occurring during that periodreinstitute hormone therapyif patient is receiving steroids alreadymay increase dosage.

MetabolicNegative nitrogen balance due to protein catabolism MusculoskeletalAseptic necrosis of femoral and humeral headsloss of muscle massmuscle weaknessosteoporosispathologic fracture of long bonessteroid myopathytendon rupturevertebral compression fractures.

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