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ACIVI Cam is indicatd th tatmnt cunt hps labialis (cold sos) in adults and adolscnts (12 yas ag and old).
In addition tadvs vnts potd om clinical tials, th ollowing vnts hav bn idntiid duing post-appoval us aciclovi cam. Bcaus thy a potd voluntaily om a population unknown siz, stimats quncy cannot b mad.
Th inhibitoy activity aciclovi is highly slctiv du tits ainity th nzym thymidin kinas (TK) ncodd by HSV and VZV. This vial nzym convts aciclovi intaciclovi monophosphat, a nuclotid analogu. Th monophosphat is uth convtd intdiphosphat by cllula guanylat kinas and inttiphosphat by a numb cllula nzyms. In vit, aciclovi tiphosphat stops plication th hps vial DNA. This is accomplishd in th ways: 1) comptitiv inhibition vial DNA polymas; 2) incopoation intand tmination th gowing vial DNA chain; and 3) inactivation th vial DNA polymas. Th gat antivial activity aciclovi against HSV compad with VZV is du tits micint phosphoylation by th vial TK.
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