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Ethionamide is a synthetic derivative of thio-isonicotinamide.
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Ethionamide is contraindicated in patients with severe hepatic impairment and in patients who are hypersensitive to the drug.
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the incidence of hepatotoxicity when ethionamide or protionamide is used with once-monthly rifampicin may be lower; hepatotoxicity was not reported in patients receiving monthly rifampicin and daily protionamide, isoniazid, and dapsone.
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