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Avoid use of nsaids, including voltaren, in pregnant women starting at 30 weeks of gestation third trimester see precautions; pregnancy .
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Diclofenac is a potent inhibitor of prostaglandin synthesis in vitroDiclofenac concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationBecause diclofenac is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Be careful drivingoperating machinery or doing jobs that require you to be alert until you know how Voltaren affects youThis medicine may cause dizzinessdrowsinessspinning sensationvertigoor blurred vision in some peopleIf you have any of these symptomsdo not driveuse machinesor do anything else that could be dangerous.
Use the lowest effective dosage for the shortest possible durationAvoid administration of more than one NSAID at a time Avoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleedingFor such patientsas well as those with active GI bleedingconsider alternate therapies other than NSAIDsRemain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapyIf a serious GI adverse event is suspectedpromptly initiate evaluation and treatmentand discontinue VOLTAREN until a serious GI adverse event is ruled outIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxismonitor patients more closely for evidence of GI bleedingsee DRUG INTERACTIONS
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